Published January 1999
by Ios Pr Inc .
|Contributions||T. Mavromoustakos (Editor), J. M. Matsoukas (Editor)|
|The Physical Object|
|Number of Pages||308|
Peptide research on drug discovery and design is an important field in the development of “peptide mimetics”, with the potential to generate important new drugs. Peptides control numerous body processes, and, as such, represent an untapped wellspring of new drugs for treating a variety of diseases. This broad and topical text describes the art to design and synthesize peptidomimetic compounds for drug discovery. In this approach, peptides and proteins are considered as hits for the discovery of other classes of compounds, named peptidomimetics, which are molecular scaffolds of different size, structure and functions, retaining the biological properties of the native peptides Cited by: peptide chemistry and drug design Download Peptide Chemistry And Drug Design ebook PDF or Read Online books in PDF, EPUB, and Mobi Format. Click Download or Read Online button to PEPTIDE CHEMISTRY AND DRUG DESIGN book pdf for free now. Over the past decade, peptide drug discovery has experienced a revival of interest and scientific momentum, as the pharmaceutical industry has come to appreciate the role that peptide therapeutics can play in addressing unmet medical needs and how this class of compounds can be an excellent complement or even preferable alternative to small molecule and biological Cited by:
design, and biostructure-based drug design. The authors also discuss drug-like properties and decision making in medicinal chemistry, chemical biology, natural products in drug discovery, and in vivo imaging in drug discovery. The middle six chapters provide an overview of peptide and protein drug design, prodrugs in drug design and development. Abstract. The past two decades have witnessed the emergence of macrocycles, including macrocyclic peptides, as a promising yet underexploited class of de novo drug candidates. Both rational/computational design and in vitro display systems have contributed tremendously to the development of cyclic peptide binders of either traditional targets such as Cited by: For biologists, the choice of chemical modification often requires expertise in chemistry through collaborations. There are, however, a number of methods that can be approached easily and yet are important for biological study of peptide drug design. First, it is necessary to identify the minimum amino acid residue(s) essential for peptide by: In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transforming a promising protein fragment or stand-alone native peptide into a pharmaceutically acceptable composition.
Bioactive Food Peptides in Health and Disease highlights recent developments on bioactive food peptides for the promotion of human health and the prevention/management of chronic diseases. The book provides a comprehensive revision of bioactive peptides obtained from both animal and plant food sources. Peptide research on drug discovery and design is an important field in the development of "peptide mimetics", with the potential to generate important new drugs. This work inludes synthesis, function, structure-activity relationships, conformation, biology, and . However, the deficiency of cell permeability and metabolic stability always limits the success of in vitro bioactive peptides as drug candidates. Peptide macrocyclization is one of the most established strategies to overcome these limitations. Over the past decades, more than 40 cyclic peptide drugs have been clinically approved, the vast Author: Xiaoshu Jing, Kang Jin. Peptides are among the most versatile bioactive molecules, yet the do not make good drugs, because they are quickly degraded or modified in the body. To overcome this problem, stable and at the same time biologically active pseudo-peptides have been developed. These novel compounds open up new perspectives in drug design by providing an entire range of highly .